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Courses/Amath 342

Connectomics and neuronal circuits

Neurons are modeled by cutting into super small sections, then bodies are colored on each frame. These frames are put back together, laying the body onto itself, creating a 3d model of a neuron (or other body) These are now done with AI

Simulation as a model for testing functional hypothesis Assumptions for our initial simulation Synapse strength: drawn from log-normal distributions Dale’s Law: All output synapses from one neurons are either excitatory or inhibitory I/E balance: Assume neurons have a similar input balance of I vs E Unobserved connections: drawn from an Erdos-Renyi network (ignore Peter’s rule)

Inhibitory/Excitatory balance I/E ratio: about 10% Synapse size is correlated with physiological strength